UV Spectrophotometric Method for the estimation of Alprazolam in Tablet Dosage Form
نویسندگان
چکیده
A simple and Sensitive UV spectrophotometric method has been developed for the determination of Alprazolam in bulk and tablet dosage form. Solution of Alprazolam in 0.1N HCl shows maximum absorbance at 260 nm. Beer’s law was obeyed in the concentration range of 1-70μg mL with 0.022x10 mol cm. The proposed method has been applied successfully for the analysis of drug in its tablets dosage forms. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excepients. The percentages assay of Alprazolam in tablet was 99.4%. The method was validated by determining its sensitivity, accuracy and precession which proved suitability of the developed method for the routine estimation of Alprazolam solid dosage form.
منابع مشابه
Application of hydrotropic solubilization in spectrophotometric analysis of Esomeprazole and Itopride pharmaceutical combined tablet dosage forms
Two simple, accurate and precise methods for simultaneous estimation of Esomeprazole and Itopride in bulk drug and tablet dosage form have been described. Method-A employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. Method -B is Absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.Beer’s law was obeyed in the con...
متن کاملSimultaneous Estimation of Ambroxol Hydrochloride and Loratadine in Tablet Dosage Form by Using Uv Spectrophotometric Method
A novel, simple, rapid, precise, accurate, cost effective and reproducible spectrophotometric method has been developed for simultaneous estimation of ambroxol hcl and loratadine in combined tablet dosage form. The method employs measurement of absorbance at two wavelengths,308nm and 245nm, of ambroxol and loratadine respectively. Beer ́s law obeyed in the concentration range of 1050μg/ml and 10...
متن کاملSimultaneous RP-HPLC and UV Spectroscopic Method Development and Validation for Estimation of Ibandronate Sodium in Bulk and Pharmaceutical Dosage Form
The present study describes a simple, accurate, precise and cost effective UV-Vis Spectroscopic and RP-HPLC method for the estimation of Ibandronate sodium (IBN). The determination of Ibandronate sodium (IBN) was performed by both UV and RP-HPLC method using 215 nm as the determination wavelength. The drug was dissolved in NaOH solution (0.1N NaOH) for estimation in UV and in distilled water fo...
متن کاملDevelopment of Validated Uv Spectrophotometric Methods for the Simultaneous Estimation of Febuxostat and Diclofenac Potassium in Tablet Dosage Form Utilising Simultaneous Equation and Absorbance Ratio Method
Two validated uv spectrophotometric methods for the simultaneous estimation of Febuxostat and Diclofenac in a multicomponent dosage form have been developed, utilising simultaneous equation and absorbance ratio method. The method is based on the measurement of absorbance of Febuxostat and Diclofenac at their respective wavelengths of 315 nm and 282nm and at the iso absorptive wavelength of 288 ...
متن کاملSpectrophotometric Analysis of Vardenafil in Tablet Dosage Forms by Using Electrophilic Coupling Reagents
Two new spectrophotometric methods (M1 and M2) are developed for the determination of vardenafil in bulk and in tablet dosage forms. The method M1 involves oxidative coupling of vardenafil with 3-methyl-2-benzothiazolinone hydrazone hydrochloride in presence of ferric chloride in acidic medium yielding green colored chromogen with absorption maxima at 625 nm. The method M2 is based on the oxida...
متن کامل